STUDY DESIGN AND RATIONALE OF EXPLORER-CN: A PHASE III, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF MAVACAMTEN IN CHINESE ADULTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY

Introduction Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease commonly caused by pathogenic genetic variants encoding sarcomere proteins.Mavacamten, a first-in-class allosteric inhibitor of cardiac-specific myosin, has demonstrated efficacy and safety in international clinical trials of patients with symptomatic obstructive HCM (oH

Abstract Background Mechanisms underlying the malignant development in bladder cancer are still not well understood.Lipolysis stimulated lipoprotein receptor (LSR) has previously been found to be upregulated by P53.Furthermore, we have previously found LSR to be differentially expressed in bladder cancer.Here we investigated the role of LSR in blad

In the Arabidopsis thaliana seed pod, pod shatter and seed dispersal properties are in part determined by the development of a longitudinally orientated dehiscence zone (DZ) that derives from cells of the gynoecial valve margin (VM).Transcriptional regulation of the MADS protein encoding transcription factors genes SHATTERPROOF1 (SHP1) and SHATTERP

Nineteen university students experimented taking on the persona of an apprehended suicide bomber.  The role play explored the psychological mechanisms of dissociative phenomena, euphoria or a sense of empowerment contemplating suicide bombing; responses of imagined secondary traumatization; identification with the victim group; creation of fic